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A.Chethikkattuveli SalihA

however as the disease progresses, pathogens in the microbiome disable the immune response and immune exhaustion occurs (233, 234)

Most recently family-based exome sequencing studies have identified rare coding variants for novel candidate genes at eight previously reported loci, with 13 additional candidates detected outside of known regions, further highlighting the multi-factorial nature of AMD (Stone, 2015